Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo

The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood. In the cerebellar cortex, molecular layer interneurons and their targets, Purkinje cells, receive excitatory inputs from granule cells and climbing fibers. Using dual patch-clamp recordings from interneurons and Purkinje cells in vivo, we probe the spatiotemporal interactions between these circuit elements. We show that single interneuron spikes can potently inhibit Purkinje cell output, depending on interneuron location. Climbing fiber input activates many interneurons via glutamate spillover but results in inhibition of those interneurons that inhibit the same Purkinje cell receiving the climbing fiber input, forming a disinhibitory motif. These interneuron circuits are engaged during sensory processing, creating diverse pathway-specific response functions. These findings demonstrate how the powerful effect of single interneurons on Purkinje cell output can be sculpted by various interneuron circuit motifs to diversify cerebellar computations

The exceptional Herbig Ae star HD101412: The first detection of resolved magnetically split lines and the presence of chemical spots in a Herbig star

We obtained high-resolution, high signal-to-noise UVES and a few lower quality HARPS spectra revealing the presence of resolved magnetically split lines. HD101412 is the first Herbig Ae star for which the rotational Doppler effect was found to be small in comparison to the magnetic splitting. The measured mean magnetic field modulus varies from 2.5 to 3.5kG, while the mean quadratic field was found to vary in the range of 3.5 to 4.8kG. To determine the period of variations, we used radial velocity, equivalent width, line width, and line asymmetry measurements of variable spectral lines of several elements, as well as magnetic field measurements. The most pronounced variability was detected for spectral lines of He I and the iron peak elements, whereas the spectral lines of CNO elements are only slightly variable. From spectral variations and magnetic field measurements we derived a potential rotation period P_rot=13.86d, which has to be proven in future studies with a larger number of observations. It is the first time that the presence of element spots is detected on the surface of a Herbig Ae/Be star. Our previous study of Herbig Ae stars revealed a trend towards stronger magnetic fields for younger Herbig Ae stars, confirmed by statistical tests. This is in contrast to a few other (non-statistical) studies claiming that magnetic Herbig Ae stars are progenitors of the magnetic Ap stars. New developments in MHD theory show that the measured magnetic field strengths are compatible with a current-driven instability of toroidal fields generated by differential rotation in the stellar interior. This explanation for magnetic intermediate-mass stars could be an alternative to a frozen-in fossil field.Comment: 7 pages, 6 figures, 1 table, to appear in Astronomische Nachrichte

Bose-Einstein condensation in a stiff TOP trap with adjustable geometry

We report on the realisation of a stiff magnetic trap with independently adjustable trap frequencies, $\omega_z$ and $\omega_r$, in the axial and radial directions respectively. This has been achieved by applying an axial modulation to a Time-averaged Orbiting Potential (TOP) trap. The frequency ratio of the trap, $\omega_z / \omega_r$, can be decreased continuously from the original TOP trap value of 2.83 down to 1.6. We have transferred a Bose-Einstein condensate (BEC) into this trap and obtained very good agreement between its observed anisotropic expansion and the hydrodynamic predictions. Our method can be extended to obtain a spherical trapping potential, which has a geometry of particular theoretical interest.Comment: 4 pages, 3 figure

Digital Discovery of a Scientific Concept at the Core of Experimental Quantum Optics

Entanglement is a crucial resource for quantum technologies ranging from quantum communication to quantum-enhanced measurements and computation. Finding experimental setups for these tasks is a conceptual challenge for human scientists due to the counterintuitive behavior of multiparticle interference and the enormously large combinatorial search space. Recently, new possibilities have been opened by artificial discovery where artificial intelligence proposes experimental setups for the creation and manipulation of high-dimensional multi-particle entanglement. While digitally discovered experiments go beyond what has been conceived by human experts, a crucial goal is to understand the underlying concepts which enable these new useful experimental blueprints. Here, we present Halo (Hyperedge Assembly by Linear Optics), a new form of multiphoton quantum interference with surprising properties. Halos were used by our digital discovery framework to solve previously open questions. We -- the human part of this collaboration -- were then able to conceptualize the idea behind the computer discovery and describe them in terms of effective probabilistic multi-photon emitters. We then demonstrate its usefulness as a core of new experiments for highly entangled states, communication in quantum networks, and photonic quantum gates. Our manuscript has two conclusions. First, we introduce and explain the physics of a new practically useful multi-photon interference phenomenon that can readily be realized in advanced setups such as integrated photonic circuits. Second, our manuscript demonstrates how artificial intelligence can act as a source of inspiration for the scientific discoveries of new actionable concepts in physics

Interaction-free measurements by quantum Zeno stabilisation of ultracold atoms

Quantum mechanics predicts that our physical reality is influenced by events that can potentially happen but factually do not occur. Interaction-free measurements (IFMs) exploit this counterintuitive influence to detect the presence of an object without requiring any interaction with it. Here we propose and realize an IFM concept based on an unstable many-particle system. In our experiments, we employ an ultracold gas in an unstable spin configuration which can undergo a rapid decay. The object - realized by a laser beam - prevents this decay due to the indirect quantum Zeno effect and thus, its presence can be detected without interacting with a single atom. Contrary to existing proposals, our IFM does not require single-particle sources and is only weakly affected by losses and decoherence. We demonstrate confidence levels of 90%, well beyond previous optical experiments.Comment: manuscript with 5 figures, 3 supplementary figure, 1 supplementary not

KRb Feshbach Resonances: Modeling the interatomic potential

We have observed 28 heteronuclear Feshbach resonances in 10 spin combinations of the hyperfine ground states of a 40K 87Rb mixture. The measurements were performed by observing the loss rates from an atomic mixture at magnetic fields between 0 and 700 G. This data was used to significantly refine an interatomic potential derived from molecular spectroscopy, yielding a highly consistent model of the KRb interaction. Thus, the measured resonances can be assigned to the corresponding molecular states. In addition, this potential allows for an accurate calculation of the energy differences between highly excited levels and the rovibrational ground level. This information is of particular relevance for the formation of deeply bound heteronuclear molecules. Finally, the model is used to predict Feshbach resonances in mixtures of 87Rb combined with 39K or 41K.Comment: 4 pages, 3 figure

0.75 atoms improve the clock signal of 10,000 atoms

Since the pioneering work of Ramsey, atom interferometers are employed for precision metrology, in particular to measure time and to realize the second. In a classical interferometer, an ensemble of atoms is prepared in one of the two input states, whereas the second one is left empty. In this case, the vacuum noise restricts the precision of the interferometer to the standard quantum limit (SQL). Here, we propose and experimentally demonstrate a novel clock configuration that surpasses the SQL by squeezing the vacuum in the empty input state. We create a squeezed vacuum state containing an average of 0.75 atoms to improve the clock sensitivity of 10,000 atoms by 2.05 dB. The SQL poses a significant limitation for today's microwave fountain clocks, which serve as the main time reference. We evaluate the major technical limitations and challenges for devising a next generation of fountain clocks based on atomic squeezed vacuum.Comment: 9 pages, 6 figure